The federal Brain Initiative aims to revolutionize understanding of the human brain through development of innovative technologies. The new data being generated pose new challenges for statistical and machine learning methods. Rob Kass chaired a working group of the American Statistical Association (http://www.amstat.org/policy/pdfs/StatisticsBRAIN_April2014.pdf) that articulated these challenges. Together with Emery Brown (MIT and Harvard Medical School), he was interviewed for Chance magazine. Kass and Brown’s book Analysis of Neural Data (http://www.springer.com/statistics/life+sciences,+medicine+%26+health/book/978-1-4614-9601-4) was published last year.