Markov chain Monte Carlo (MCMC) methods make possible the use of flexible Bayesian models that would otherwise be computationally infeasible. In recent years, a great variety of such applications have been described in the literature. Applied statisticians who are new to these methods may have several questions and concerns, however: How much effort and expertise are needed to design and use a Markov chain sampler? How much confidence can one have in the answers that MCMC produces? How does the use of MCMC affect the rest of the model-building process? At the Joint Statistical Meetings in August, 1996, a panel of experienced MCMC users discussed these and other issues, as well as various "tricks of the trade". This paper is an edited recreation of that discussion. Its purpose is to offer advice and guidance to novice users of MCMC - and to not-so-novice users as well.
Topics include building confidence in simulation results, methods for speeding convergence, assessing standard errors, identification of models for which good MCMC algorithms exist, and the current state of software development.