Pantelis K. Vlachos

Research computational advances have made it feasible to fit sophisticated models in a wide range of serious applications. Some of my recent research has focused in the model checking aspect of hierarchical models using simulation based methods.

I have also used such methods as a tool for design and analysis of sequential clinical trials. Such trials usually last for several months, even years and consume substantial financial and patient resources. Thus, inspecting the data as it accumulates and terminating the trial if evidence of one treatment's superiority emerges have become essential. My work involves developing methods for implementing and assessing optimal designs for such trials.

Related Publications

Vlachos, P.K. and Gelfand, A.E. (1996). "Nonparametric Bayesian Clinical Trials Design for Continuous Patient Response," submitted.

Dey, D.K., Gelfand, A.E., Swartz, T.B. and Vlachos, P.K. (1995) "A Simulation-Intensive Approach for Checking Hierarchical Models," submitted.

Vlachos P.K. and Gelfand, A.E. (1995) "Issues in the Bayesian Design of Clinical Trials with Multiple Categorical Endpoints," Proceedings of the ASA Section on Bayesian Statistical Science, pp. 1-6.